Great thread and post, @flohmann!
Since last summer, after two years of tweaking, I settled on:
PC running iTunes (source: soon to be iMac or Mini)
Airport Extreme (wifi router)
Airport Express (streamer: older version, older firmware--solved dropping issues)
Wyred 4 Sound Remedy Reclocker
Wyred 4 Sound DAC-2 (as preamp for 2-channel)
JOB 250 (2-channel amp)
Monitor Audio Silver RX6 (mains)
For the moment, I could NOT be any happier.
My evolution took me through a 13-year-old Marantz receiver, Audio-GD DAC, Parasound 2100 preamp and Channel Island Audio PLC-1 MKII passive preamplifier before settling on this 2-channel setup. I have equipment space considerations and the need of HT bypass for a small town home living room. Nothing is ever ideal, but I am completely entranced with my music library like never before.
JP